Platelet inhibiton by sodium nitroprusside, a smooth muscle inhibitor
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Platelet inhibition by sodium nitroprusside, a smooth muscle inhibitor.
The effects of sodium nitroprusside (N.P.), a pure smooth muscle inhibitor, on platelet function were studied. Platelet-rich plasmas (PRP) from normal controls and from patients receiving N.P. were studied in vitro for aggregation in response to adenosine diphosphate (ADP), epinephrine, and collagen. Platelet ADP release (release reaction) was also investigated. Normal platelets demonstrated ma...
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Nitric oxide (NO) relaxes most smooth muscle, including the circular smooth muscle (CSM) of the esophagus, whereas in the adjacent longitudinal smooth muscle (LSM), it causes contraction. The second messenger pathways responsible for this NO-induced LSM contraction are unclear, given that these opposing effects of NO are both cGMP dependent. In intestinal LSM, but not CSM, cADP ribose (cADPR)-d...
متن کاملSodium in smooth muscle relaxation
MA, T. S., AND D. BOSE. Sodium in smooth muscle reluxation. Am. J. Physiol. 232(l): C59-C66, 1977 or Am. J. Physiol.: Cell Physiol. l(1): C59-C66, 1977. -The contraction of guinea-pig taenia coli due to high K+ could not be reversed by washing when Na+ was absent from the medium. Reintroduction of Na+ (7 mM or more) caused relaxation. Similar results were obtained with rat uterus. The effect of...
متن کاملSodium in smooth muscle relaxation
MA, T. S., AND D. BOSE. Sodium in smooth muscle reluxation. Am. J. Physiol. 232(l): C59-C66, 1977 or Am. J. Physiol.: Cell Physiol. l(1): C59-C66, 1977. -The contraction of guinea-pig taenia coli due to high K+ could not be reversed by washing when Na+ was absent from the medium. Reintroduction of Na+ (7 mM or more) caused relaxation. Similar results were obtained with rat uterus. The effect of...
متن کاملSodium in smooth muscle relaxation.
The contraction of guinea-pig taenia coli due to high K+ could not be reversed by washing when Na+ was absent from the medium. Reintroduction of Na+ (7 mM or more) caused relaxation. Similar results were obtained with rat uterus. The effect of sodium replacement was not due to change in ionic strength because equal or higher osmoles of choline, Ca++, K+, Mn++, or Mg++ had little or no effect. P...
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ژورنال
عنوان ژورنال: Blood
سال: 1976
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v47.6.957.957